![]() ![]() A more recent study by Martin and colleagues, using data from 2001, found 5.7 million physician/emergency room visits were constipation related. In the United States, physician visits from 1958 to 1986 for constipation averaged 2.5 million per year. Bowel symptoms consistently improved over 48 weeks in adult patients with chronic idiopathic constipation.Ĭonstipation is a common complaint, with prevalence estimates ranging from 2–28% in the United States constipation is also found more commonly in women and the elderly. Conclusionsĭuring this 48-week open-label study, lubiprostone was well tolerated. On average, lubiprostone significantly ( p < 0.0001) reduced patient-reported constipation severity, abdominal bloating, and abdominal discomfort across 48 weeks when compared to baseline. Average changes in serum electrolytes were not clinically relevant at any time point during the study. ![]() No deaths were reported and of the 16 reported serious AEs, one was considered possibly treatment related. The most common treatment-related AEs were nausea (19.8%), diarrhea (9.7%), abdominal distension (6.9%), headache (6.9%), and abdominal pain (5.2%). A dose reduction was observed in 17% of the patients, resulting in an average study medication exposure across the study of approximately 1.7 capsules (or approximately 40.8 mcg) per day. Of the 248 patients who entered the trial, 127 (51%) completed the trial. Hematology and chemistry profiles and assessment of constipation symptoms and its severity were performed at all visits. Patients were allowed to decrease the dose in response to the perceived severity of constipation and need for relief. In this prospective, multicenter, open-labeled trial, 248 patients aged ≥18 years with chronic idiopathic constipation were directed to take lubiprostone 24 mcg BID as needed for 48 weeks. To examine the long-term safety and effectiveness of lubiprostone in patients with chronic idiopathic constipation. There are limited data on long-term pharmacological treatment with lubiprostone for chronic idiopathic constipation. If you think you may have a medical emergency, call your physician or 911 immediately.Lubiprostone helps relieve constipation in short-term 4-week studies. By using this Site you agree to the following Terms and Conditions. We offer this Site AS IS and without any warranties. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. ![]()
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